#XANTHOCHROMIC CSF TRIAL#

G., Steiner, L.: Spectrophotometry of cerebrospinal fluid in subacute and chronic subdural haematomas. Plenum Press, New York, 1983, Chapter 20.

(ed.): Neurobiology of Cerebrospinal Fluid 2.

G., Siden, A.: Cerebrospinal fluid proteins in infectious Neurological Diseases and Guil-lain-Barré syndrome. (eds.): International Conference on Atherosclerosis. (ed.), Analytical Isotachophoresis, Amsterdam, Elsevier, 1981. G., Hallander, L.: Isotachophoresis of xanthochromic compounds in the cerebrospinal fluid. (ed.): Proceedings of the Fourth International Meeting of the International Society for Neurochemistry, Vol. G.: Isoelectric focusing of protein compounds in the cerebrospinal fluid. In Proceedings of the Annual General Meeting of the Swedish Society of Medical Sciences Stockholm, 1971, p. G.: Xantokroma protein-Foreningar i Likvor. G.: The binding of xanthochromic compounds in the cerebrospinal fluid. G.: The CSF iron in patients with neurological diseases. G.: The diagnostic value of spectrophotometry of the CSF in the newborn period. Q.: The nature and clinical significance of pigments in the cerebrospinal fluid. This process is experimental and the keywords may be updated as the learning algorithm improves.Īntoni, N.: Om lumbal punktion. These keywords were added by machine and not by the authors. Furthermore, surface bleeding near boney structures such as subarachnoid hemorrhages (SAHs) may escape diagnosis, and the hemorrhagic component in cerebral infarctions may be difficult to detect by CT.

Unfortunately, such needed equipment is rather complicated and expensive and, for the present, is available only in major medical centers. The introduction of cranial computed tomography (CT) represents an extremely valuable improvement in the detection of intracranial vascular lesions including hemorrhage and infarction. However, the diagnostic information from these findings is often insufficient despite the addition of other clinical data. © 2023 Andrei Neagu et al., published by Sciendo.The presence of erythrocytes in cerebrospinal fluid (CSF), a leukocyte pleocytosis, increased CSF protein concentration, and xanthochromia of centrifuged CSF are important findings in the detection of vascular neurological disorders (see Vol. The diagnosis of carcinomatous meningitis requires an extensive workup for exclusion of infectious causes which is important for urgent oncologic treatment.įever glioblastoma meningitis xanthochromic CSF. The case describes an unusual clinical presentation of a patient with glioblastoma associated leptomeningeal dissemination, as high fever and xanthochromic CSF could raise important diagnostic and therapeutic challenges in the clinical practice.

#XANTHOCHROMIC CSF TRIAL#

A therapeutic trial of standard antituberculous drugs with repeated lumbar punctures were needed in order to exclude Mycobacterium tuberculosis and to confirm the diagnosis of carcinomatous meningitis by cytopathological examination of the CSF. CSF was analyzed for typical bacterial and viral causes, but also pathogens associated with immunosuppression, such as Listeria monocytogenes and Cryptococcus neoformans. An extensive workup especially with molecular microbiology testing for exclusion of infectious causes was performed. Her past medical history was significant for a left temporal glioblastoma, treated with surgical resection and adjuvant chemo- and radiotherapy, with associated systemic immunosuppression secondary to chemotherapy. Diagnosis is challenging, as the sensitivity of classic diagnostic investigations remains low for detecting cerebrospinal fluid (CSF) tumor spread and exclusion of infectious causes is mandatory, especially if unusual clinical findings are present.Ī 71-year-old woman was admitted to our hospital for recurrent episodes of high fever and xanthochromic meningitis, with subacute onset. Leptomeningeal spread with carcinomatous meningitis is a severe complication of glioblastoma, with a poor prognosis.

Xanthochromic csf